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Toxicogenomics : the future of toxicity testing
The European Commission estimates that the overall financial burden arising from the deleterious effects on human health due to the 100,000 synthetic chemicals in our environment will amount to 52 billion euros. Although the aim of REACH is to avoid this catastrophic scenario, the ultimate outcome will depend on the accuracy and robustness of the test methods used in this programme. The fact that animal tests are a major component of REACH does not inspire confidence and is indeed a cause for concern.
To rely on crude animal data in an era of modern toxicology simply does not make sense. Huge advances have taken place over the last two decades, giving birth to the new science of toxicogenomics - the marriage of molecular toxicology and bioinformatics - which allows thousands of chemicals to be tested in a matter of hours or days, rather than the months or years associated with traditional animal experiments. In addition, the biological material used in toxicogenomic studies is derived from cell cultures of human origin. This makes the data obtained all the more relevant to the species in question - human beings.
Advantages of toxicogenomics
1. Reliability. Until very recently, toxicology testing was based largely on animal experiments - described by Dr Thomas Hartung, director of ECVAM (European Centre for the Validation of Alternative Methods) as representing "simply bad science" (Nature, 10 November 2005).
4. EU innovation. BioTeSys (Germany), Scienion (Germany), and Vigilent Technologies (France) are examples of three European enterprises that share a novel approach to toxicogenomics. This technological advantage potentially places the EU ahead of its US and Japanese counterparts, with respect to patent applications.
5. Ethics. The adoption of toxicogenomics within REACH will eliminate the need for animal testing.
All of the above clearly
supports the establishment of a European Centre for toxicogenomics,
with the following associated benefits: