scientific committee promoting sound science

For a strong REACH

dino2The European Commission estimates that the overall financial burden arising from the deleterious effects on human health due to the 100,000 synthetic chemicals in our environment will amount to 52 billion euros. Although the aim of REACH  is to avoid this catastrophic scenario, the ultimate outcome will depend on the accuracy and robustness of the test methods used in this programme. The fact that animal tests are a major component of REACH does not inspire confidence and is indeed a cause for concern.

To rely on crude animal data in an era of modern toxicology simply does not make sense. Huge advances have taken place over the last two decades, giving birth to the new science of toxicogenomics — the marriage of molecular toxicology and bioinformatics — which allows thousands of chemicals to be tested in a matter of hours or days, rather than the months or years associated with traditional animal experiments. In addition, the biological material used in toxicogenomic studies is derived from cell cultures of human origin. This makes the data obtained all the more relevant to the species in question — human beings.

Advantages of toxicogenomics


Until very recently, toxicology testing was based largely on animal experiments – described by Dr Thomas Hartung, director of ECVAM (European Centre for the Validation of Alternative Methods) as representing “simply bad science” (Nature, 10 November 2005).


The European Commission estimates that it will cost 2.8 – 3.6 billion euros in order to test just 12,000 chemicals.

Antidote Europe estimates that 1.5 billion euros would be sufficient to establish a European Centre for toxicogenomics in which to test the 100,000 chemicals considered to be in our environment. An added incentive is that the cost of testing would be shared primarily among EU member states and not by industry alone.


According to the European Commission, it would take several decades to test 12,000 chemicals. The US National Toxicology Program estimates that three years of animal testing are required in order to evaluate one single chemical.

In contrast, Antidote Europe estimates that it would take two years in order to evaluate 100,000 chemicals, using toxicogenomics. This is because 1,000 substances can be tested simultaneously and no chemical would require more than one week to evaluate.


BioTeSys (Germany), Scienion (Germany), and Vigilent Technologies (France) are examples of three European enterprises that share a novel approach to toxicogenomics. This technological advantage potentially places the EU ahead of its US and Japanese counterparts, with respect to patent applications.


The adoption of toxicogenomics within REACH will eliminate the need for animal testing.


All of the above clearly supports the establishment of a European Centre for toxicogenomics, with the following associated benefits:

  • 50 billion euros in saved health costs, in addition to reduced chemical pollution as a result of banning substances found to be highly toxic
  • unfettering small businesses, since the burden of chemical testing will be shared among EU member states and not industry
  • support of technological innovation
  • approval and support from the animal welfare community.


People are not 70kg rats

dgbgldf,ml,l, dflkkjlk , fkl,mlgojhndjghldfk, 5 April 2011: The optimum time to get a new drug on to the market from its discovery to its sale is 12 years, at a cost of around 500 million euros. The clinical (in human) phase of drug development is by far

Ban cosmetics testing on animals now!

ban-cosmetics-testing 15 November 2010:  After decades of campaigning by animal welfare groups, the 7th amendment to the EU Cosmetics Directive was hailed as a strategic achievement and a major milestone towards the replacement of animals in cosmetic tests. On the face of it, the

Danger, Bisphenol!

danger-bisphenol2 9 June 2010: Bisphenol A (BPA) is a synthetic chemical composed of two phenol rings joined together by a carbon atom. It is manufactured in huge quantities (3 billion kg/year) for use in the production of polycarbonate plastics (e.g. dummies, inside lining of tinned foods

Cancer Test

uomo-paper-bg-710 9 June 2010: Antidote continues to actively promote toxicogenomics as the modern method of choice for hazard and risk assessment of chemicals, which must be adopted without delay by the regulatory authorities, especially in REACH. This method has shown itself to be rapid, cost

28 Chemicals

9 June 2010: Introduction The aim of this work is to introduce a method that is considered reliable for assessing the toxicity of chemical substances. This goal of safety for human health cannot be achieved through the use of standard toxicology methods, which